OUR SCIENCE
Science designed to reveal what DNA alone cannot.
Functional precision oncology adds another dimension to cancer research by observing how living tumor cells respond to potential therapies.
Actual ovarian cancer organoids
FUNCTIONAL PRECISION ONCOLOGY
See biology in action.
Genomic and functional approaches provide two complementary sources of information about an individual cancer.
Genomics
What alterations are present?
Molecular profiling identifies genetic alterations that may provide insight into cancer biology and potential treatment options.
Functional Response.
How do living cells respond?
Functional testing directly measures how living tumor cells respond when exposed to potential therapies.
THE PARIS® PLATFORM
Live tumor sample.
Multiple therapies.
Functional response.
The PARIS platform applies functional precision oncology by testing live, patient-derived tumor cells against multiple therapies and measuring their response.
These functional results provide another layer of information that can be considered alongside molecular findings and other clinical information.
EXPLORE THE PARIS TEST >
BEYOND GENOMICS
Discover vulnerabilities DNA may not show.
Functional approaches can reveal biological dependencies and treatment responses that may not be apparent from genomic information alone.
Synthetic Lethality
Identify vulnerabilities
Investigate relationships between biological pathways that may reveal potential cancer-cell vulnerabilities.
Drug Response
Drug Response
Observe how living tumor cells respond to potential therapies under controlled laboratory conditions.
RESEARCH & DISCOVERY
A platform for exploration.
Functional approaches create opportunities to investigate cancer biology, therapeutic response and new research questions.
Cancer Biology
Explore the pathways and dependencies that influence cancer-cell behavior.
Drug Screening
Evaluate the response of living tumor cells to potential therapies and combinations.
Clinical Research
Investigate how functional information may complement molecular and clinical data.
PUBLISHED SCIENCE
Follow the evidence.
Explore the scientific research behind Cure First and functional precision oncology.
Publications
Peer-reviewed Research
Published research exploring functional precision oncology and related scientific approaches.
Case Reports
Clinical Observations
Reports describing functional precision oncology in individual clinical settings.
Posters
Scientific presentations
Posters, abstracts and presentations from Cure First and its collaborators.
COLLABORATE WITH CURE FIRST
What could we discover together?
Cure First collaborates with researchers, clinicians, cancer centers and industry partners interested in advancing functional precision oncology and exploring new questions in cancer biology and therapeutic response.
Cancer Centers • Investigators • Clinical Research • Industry